By D. Kabelitz, T. Pohl, K. Pechhold (auth.), Guido Kroemer, Carlos Martinez-A. (eds.)
In any circulation in their existence, immune cells, in particular T and B lymphocytes, are faced with a vital selection: to proceed their life or to devote a type of metabolic suicide that's often called apoptosis or programmed telephone loss of life. not like such a lot philosophers, lymphocytes and their precursors are regularly vulnerable to suicide, and it even seems that the standard reason behind T or B telephone removal is suicide instead of demise from average motives, injuries or homicide. This booklet presents an unlimited evaluate of lymphocytes suicide: exterior triggers and inner reasons resulting in suicidal impulses, accomplices in self-destruction, guns implicated in self-execution, elimination of useless our bodies and pharmacological prevention of suicide. lots of the chapters during this ebook are dedicated to the body structure of apoptosis. The objective is to unmask the exterior triggers of apoptosis, resolve the sign transduction seasoned cesses concerned therein and describe the position of oncogenes, "death genes" and effector molecules within the apoptotic cas cade. the remainder chapters care for the pathophysiologi cal points of lymphocyte apoptosis, specifically, as a bunch contribution to HIV-induced lymphopenia, and healing thoughts for the avoidance of lymphocyte dying. we're convinced that this compendium will give a contribution to the exploration of mobile suicide, not just from a simple scientist's perspective but additionally in regards to the potential scientific implications of apoptosis (dys)regulation. faraway from having a dismal impression at the reader, mobile suicide may well therefore offer a resource of either highbrow pleasure and healing inspiration.
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Extra resources for Apoptosis in Immunology
48 1 Introduction The immune system is endowed with a multitude of different mechanisms to eliminate, paralyze or neutralize T and B lymphocytes expressing self-reactive antigen receptors that might endanger the individual's life. The ability of both types of lymphocytes to recognize and react to different stimuli is a learning process that occurs during lymphocyte differentiation, and the mechanisms implicated in self-tolerance intervene at determined control points following developmental criteria.
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