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Plasma membrane-associated channels referred to as hole junctions, besides their protein construction blocks—connexins—have a huge practical position in a number of immunological tactics, together with middle functionality, telephone development and specialization, and early improvement. Spanning uncomplicated technology and strength medical functions, Connexin phone conversation Channels: Roles within the Immune approach and Immunopathology assembles and synthesizes 4 many years of an important examine conducted during this box.
Autophagy, an infection, and the Immune Response provides a unified assessment of the jobs of mobile autophagy in the course of microbial an infection. Introductory chapters ground the reader by means of laying out the autophagic pathway from a mobile perspective, and directory assays on hand for measuring autophagy. next chapters address virus interactions with autophagy equipment, a number of the roles of autophagy parasitic an infection, and interactions of micro organism with the autophagic pathway.
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The Evolution of the Immune approach: Conservation and Diversification is the 1st ebook of its style that activates a brand new viewpoint while describing and contemplating the evolution of the immune method. Its new angle summarizes, updates, and gives new insights at the diverse immune receptors, soluble components, and immune cellphone effectors.
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Additional resources for Annual Review of Immunology Volume 16 1998
1997. Interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein. J. Clin. Invest. 99:2930–40 15. Smith MF Jr, Eidlen D, Brewer MT, Eisenberg SP, Arend WP, GutierrezHartmann A. 1992. Human IL-1 receptor antagonist promoter. Cell type-specific activity and identification of regulatory regions. J. Immunol. 149:2000–7 16. Smith MF Jr, Eidlen D, Arend WP, Gutierrez-Hartmann A. 1994. LPSinduced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements.
Effect of Treatment in Animal Models of Disease The beneficial effects of administration of recombinant human IL-1Ra in many experimental animal models of disease are summarized in recent reviews (5–7). Table 2 contains an incomplete listing of some animal models where the delivery of exogenous IL-1Ra, usually intravenously, led to at least partial prevention or treatment of disease. A potential limitation to the therapeutic use of IL-1Ra protein is the necessity to administer large amounts. Up to 100- to 1000-fold amounts of IL-1Ra greater than the IL-1 agonists were necessary to inhibit biologic activities (153).
1994. A physical map of the region encompassing the human interleukin-1α, interleukin1β, and interleukin-1 receptor antagonist genes. Genomics 19:382–84 22. Tarlow JK, Blakemore AIF, Lennard A, Solari R, Hughes HN, Steinkasserer A, Duff GW. 1993. Polymorphism in human IL-1 receptor antagonist gene intron 2 is P1: NBL/PLB P2: NBL/plb January 19, 1998 48 23. Annu. Rev. Immunol. 16:27-55. org by HINARI on 08/31/07. For personal use only. 24. 25. 26. 27. 28. 29. 30. 31. 32. 14:7 QC: NBL Annual Reviews AR052-02 AREND ET AL caused by variable numbers of an 86-bp tandem repeat.