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Extra resources for Annual Review of Immunology Volume 12 1994
No one considered the obligatory linkage between recognitive potential and effector function. For example, Jerne (33) considered aggregative interaction between "natural" antibody and antigen that had as a consequence(effector function) the cellular uptake and replication the "natural" antibody, but he never considered that a concentration of "natural" antibody high enough to carry out that effector function would be high enoughto carry out other effector functions, which are destructive. He repeated the same error 20 years later when he proposed regulation via an idiotype network.
Mmalstate) Signal[I] (anticipatory +interleukins " ~’""~’~-cell state) Signals[I]+ (sensifizedstate) ~ ~’--~ e-cells Division and (effector differentiation state) The decision between the two pathways inactivation (tolerance) and sensitization to responsiveness to interleukins depends upon the insufficiency or sufficiency of effector T-helpers (eT"). Duringfetal life, wheni-cells are being generated, there is an insufficiency of eTH. Consequently, all i-cells anti-Self (anti-S) are deleted by interaction with Self(S).
Weknewby direct assay, that the ~:2~ ratio in murine serum was ~ 30:1. l-gene segment. There had to be a reason why the single V~-genesegmentwas maintained in a separate locus, and this reason had to be unique antigenic selection that woulddisproportionately raise the expressed level of V~C~thus lowering the observed ~::2~ ratio. Eventually, weighing the pluses and the minuses, we settled for an order of magnitude estimate of ~ 102 functional V,,-gene segments. Howdid we knowthat ¯ there was only one V)~-gene segment?