Download Annual reports in medicinal chemistry, 1969 by Cornelius Kennedy Cain; American Chemical Society. Division PDF

By Cornelius Kennedy Cain; American Chemical Society. Division of Medicinal Chemistry

ISBN-10: 0080583490

ISBN-13: 9780080583495

ISBN-10: 0120405059

ISBN-13: 9780120405053

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Analogue (14) has been shownl5 to have both analgesic and morphine-antagonThe cis and trans forms of 3-methylmeperidine (15) were ist properties. Several both the cis ten times more potent than the trans. fentanyl analogues (16)showed good analgesia33 but none with separation of analgesic and side effects. 34 Its capacity to precipitate the morphine abstinence syndrome was demonstrated35 alsng with its failure to substitute f o r morphine in dependent subjects. 3~ Tae amidodrawal. 34 - Sect. I - CNSAgents Childress, Ed.

O. Ogunlana, E. E. , J. Pharm. S c i . 58, 143 (1969). 22. G. G. F l o s s , D. Groeger and D. Erge, J. Chem. SOC. D , 418 (1969). 23. J . E . G. F l o s s , Tetrahedron L e t t . 1857 (1969). 24. D. Groeger, Biosyn. A l k a l o i d e , 486 (1969). 7 1 , 91451c (1969). 25. F. T r o x l e r and A. Hofmann, Swiss 473,127; Chem. Abstr. - 1. - XF. 14, Chap. 3 Hallucinogens Razdan 29 - 26. F. Troxler, Fr. M. 4,946; Chem. Atstr. 71, 113139m (1969). 27. F, Troxler, J. Rutschmann and E. Schreier, Swiss 459,243; Chem.

Cerny and M. Semonsky, Collect. Czech. Chem. Commun. 34, 694 (1964). 29. M. Julia, F. LeGoffic, J. Igoler and M. Baillarge, TetraGdron Lett. 1569 (1969). 30. J. Agurel1, { b i d . , 3371 (1969). 31. G. L. Khanna, H. Rosenberg and M. Takido, J. Chem. SOC. D, 838 (1969). 32. J. N. E. Fayez, J. Pharm. Sci. 58, 1157 (1969). 33. R. Battersby, R. Binks and R. Huxtable, Tetrahedron Lett. 6111 (1968). 34. J. M. Fales, Chem. Commun. 1688 (1968). 35. 0. H. Osamu, Y. L. Karle and B. Witkop, 3. her. Chem. SOC.

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