By Nobuyo Maeda, Nobuo Tamiya, Y. M. Chen, C. Y. Lee (auth.), Akira Ohsaka, Kyozo Hayashi, Yoshio Sawai, Ryosuke Murata, Masaru Funatsu, Nobuo Tamiya (eds.)
During the previous twenty years, learn on animal, plant, and microbial pollution has accelerated swiftly, and new and fascinating details has looked as if it would make clear either the scientific and healing features of intoxication and, much more impor tant, to assist us comprehend extra precisely the constitution and the mode of motion of poisons on a molecular foundation. due to the interdisciplinary nature of toxin study, it really is of significant impor tance that staff focusing on its varied features may still make a specific attempt to interchange and stay alongside of new advancements during this rapidly-expanding box. This has been one of many major reasons of the sequence of foreign conferences which were held during the last ten years. The expanding curiosity within the result of toxin study could be defined partially by means of the turning out to be common preoccupation with pollutants and its poisonous results, which means extra anq extra experts in different fields are discovering it essential to keep up a correspondence with present examine into clearly taking place pollutants. The papers in those volumes have been awarded on the Fourth foreign Symposium on Animal, Plant and Microbial pollution, prepared by means of the Inter nationwide Society on Toxicology, held in Tokyo in September, 1974. The editors have determined to incorporate either unique reviews and evaluation articles, prepared in response to disciplines. modifying has been saved to the minimal important for enough comprehension of the materials.
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Additional info for Animal, Plant, and Microbial Toxins: Volume 2 Chemistry, Pharmacology, and Immunology
Similarities between Notexin and a Basic Phospholipase from Naja nigricollis Venom. The basic N. 5. This basic phospholipase is similar to the phospholipase AI isolated earlier in this laboratory (Wahlstrom, 1971) from N. nigricollis venom of different origin, and shows about the same toxicity in mice. The reduced and S-carboxymethylated derivative of the basic PLase is cleaved in better than 90% yield at both of its methionine residues upon treatment overnight in 70% formic acid with a 30-fold molar excess of cyanogen 32 D.
Twelve of the 14 halfcystine residues in notexin align nicely with the twelve half-cystines of the pancreatic enzyme, the remaining two at positions 45 and 100 (homology numbering) being represented by deletions. , 1970b) the seventh bridge would connect these two residues. Notexin shows still higher homology with the N. melanoleuca phospholipase, as illustrated in Fig. 4. But again, only 9 of 34 positions are identical in the stretch between Lys-57 and Cys-92 (homology numbering). However, this does not necessarily imply that the structural features responsible for the neurotoxicity of notexin reside in that region, since the two phospholipases are also very different in the same stretch.
Tokyo, Japan), it is desirable to obtain relatively large fragments, which may be digested further when necessary (Fig. 9). Citraconylation was carried out as described by Gibbons and Perham (l970) with slight modifications (Maeda and Tamiya, 1974). 6 X 74 cm) chromatography. 8, for 16 hr at 37°C. ectrqD:>resis ClynDtryptic digestion (62') (15\) . I\E-cellulooe chranatography A-3b-1 . 9. Enzymatic fragmentation of RCM-LsIIl . The percentage values are the yields of the pep tides at each digestion step.