Download Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann PDF

By Burkhard Ludewig, Matthias W. Hoffmann

ISBN-10: 1588294064

ISBN-13: 9781588294067

ISBN-10: 1592598625

ISBN-13: 9781592598625

An authoritative selection of optimum ideas for generating and characterizing the immunologically lively cells and effector molecules now gaining broad use within the medical therapy of sufferers. profiting from the most recent applied sciences, the authors current quite simply reproducible experimental protocols for the examine of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and medical purposes and at the growth of chosen methods in medical trials. extra chapters disguise the molecular definition of goal antigens, mathematical modeling methods to immunotherapy, and the usage of regulatory T cells. The protocols give the opportunity to check the adoptive move of adapted antigen-specific immune cells and to enhance the medical program of adoptive immunotherapy.

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16 O’Neill and Bhardwaj 99. , et al. (2002) A clinical grade cocktail of cytokines and PGE(2) results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy. Vaccine 20(Suppl. 4), A8–A22. 100. , and Groettrup, M. (2002) Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood 100, 1354–1361. 101. 101 Alexander-Miller, M. , Leggatt, G. , and Berzofsky, J. A. (1996) Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

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