By Pierre Hainaut, Klas G. Wiman
The invention of p53 in 1979 marks the start of a such a lot interesting period of contemporary melanoma study and molecular biology, an period that continues to be in complete swing and doesn't convey any indicators of finishing within the foreseeable destiny. p53 has emerged as a key tumor suppressor and significant objective for novel melanoma treatment. For round 10 years, p53 was once thought of an oncogene with a bit of strange positive aspects. despite the fact that, a tremendous paradigm shift happened round 1988-89 while fascinating new findings validated that standard (wild style) p53 may perhaps inhibit transformation of cells in tradition and that the p53 gene was once mutated in a wide fraction of human tumors. in truth, p53 looked to be the main usually mutated gene in melanoma cells. next paintings in the course of the 1990’s confirmed that p53 was once a transcription issue that regulates many different genes, and that p53 can set off apoptosis, the suicide application of the telephone. This ebook, written through world-leading p53 researchers together with a lot of those that have formed the sector during the last 25 years, offers designated insights into the growth of the p53 box and the customers for higher melanoma analysis and treatment sooner or later. it may be of curiosity to every person operating in melanoma study, scientific oncology, and molecular biology, and certainly to anyone drawn to technological know-how, medication, in addition to in fresh advancements of the guidelines and ideas of the molecular biology of melanoma.
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Extra info for 25 Years of P53 Research
Oncogene 1996; 13:2477-82. , Prives C. The C-terminus of p53: the more you learn the less you know. Nat Struct Biol 2001; 8:730-2. , Roeder R. G. Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53. Cell 2004; 117:735-48. Anderson M. , Tegtmeyer P. Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation. Mol Cell Biol 1997; 17:6255-64. , Anderson C. W. Post-translational modifications and activation of p53 by genotoxic stresses.
Insights from studies of wild-type p53 Research focused on the DNA binding properties of the central domain have yielded interesting clues as to possible modes of regulation and the molecular mechanism of DNA binding. , 2002). , 1997a). Furthermore, Nagaich et al. have proposed that a 2. , 1997b). Therefore DNA conformation is a potential way to regulate DNA binding through the core domain. , 1998), although whether this ability requires the p53 core is not fully understood. , 1994; Zhou & Prives, 2003).
Isolation of p53-target genes and their functional analysis. , 2004. 95:. 7-11. , Hostetter R. , Vogelstein B.. Mutations in the p53 gene occur in diverse human tumor types. Nature, 1989. 342: 705-708. , Prives C. Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell, 2002. 9: 761-771. , Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature, 1992. 358: 15-16. J. Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proceedings of the National Academy of Sciences USA, 1983.